Purdue vs Michigan State Odds, Spread & Prediction (Friday, Nov. 22)

• Michigan State hosts Purdue Friday night, needing a win to keep its bowl eligibility alive
• The Boilermakers have lost nine straight games
• Read below for Purdue vs Michigan State betting line, prediction and pick

The math is simple for the Michigan State Spartans (4-6, 2-5 Big Ten): close out the regular season with two straight wins, and they go bowling.

The first of those tasks comes Friday, when they host the Purdue Boilermakers (1-9, 0-7 Big Ten).

There’s no softer part of the schedule late in the season than right here, as Purdue has lost nine straight games and are heavy underdogs in the college football odds.

MSU isn’t exactly soaring into the matchup either, having dropped three in a row and six of its last seven.

Purdue vs Michigan State Odds

Still, the Spartans are pegged as 13.5-point favorites, with the total set at 48.5 points.

Kickoff is scheduled for 8pm ET at Spartan Stadium in East Lansing, Michigan, with FOX carrying the broadcast.

Odds as of November 21 at 10pm ET. Be sure to check out the best Caesars Sportsbook promos before placing a bet on any Week 13 College Football matchup.

Spartans Still Alive

If Michigan State is going to get to six wins, the offense is going to have to put up some points.

The Spartans are coming off a 38-16 whipping at the hands of Illinois the last time out, the fifth time in the last six games they have scored 17 points or less.

MSU is a Bottom-4 scoring team in the Big Ten this season, putting up 19.4 points per game.

WOW… Michigan State responds with a TD!! 🙌 @MSU_Football pic.twitter.com/v8Q8kq8eiO

— FOX College Football (@CFBONFOX) November 16, 2024

While the passing game is Top 10 in the conference, putting up 230.8 yards per contest, they are getting little from the running game, which puts up less than 115 rush yards per game.

That hasn’t been enough to support what’s been a good defense, which ranks 33rd in the nation in yards allowed, while inside the Top 45 in both rush and passing yards allowed.

Boilermakers Try to Play Spoiler

If Purdue wants to salvage what’s been an absolutely horrid year, the last two weeks couldn’t be better set up.

They can put an end to MSU’s bowl dreams, and could potentially be facing an undefeated Indiana team, or clinging to its playoff hopes needing a blowout victory.

THE DOUBLE PASS!! pic.twitter.com/BBqmqArEMN

— CBS Sports (@CBSSports) November 16, 2024

The Boilermakers will need to show some life, though. Other than OT losses to Illinois and Northwestern, their other seven losses during this streak have been by 17 points or more.

Purdue was crushed by Penn State 49-10, a week after getting clubbed 45-0 by Ohio State. They are the Big Ten’s biggest defensive sieve, allowing a massive 38.9 points per game. Teams are rolling up 455.7 yards per game, while ranking 114th in passing and 120th in rushing.

They’re also the conference’s lowest-scoring side, putting up 17.2 per contest.

Purdue vs Michigan State Prediction

These teams haven’t met since 2021, when Purdue got on the board with a 40-29 W. That snapped an 8-game losing streak to the Spartans, who have won five of those eight by double digits.

I get it’s hard to trust MSU at this point, as they are just 4-6-0 against the spread, and have only been favored twice this season, going 0-2-0 ATS. Purdue is also 5-1-0 ATS over the last six meetings.

Purdue vs Michigan State Last 5 games

That being said, we’re far from 2021, and Purdue’s defense has only kept one road game this season within 15 points.

Michigan State has a respectable passing attack, and a run game that’s been put on ice the last two games as they’ve been playing catch-up. They now get a chance to let loose against a unit allowing 203.3 yards on the ground per game to help beef up the passing game.

Add that to the MSU desperation component, and this should add up to a 2-TD triumph.