Memphis vs Tulane Prediction, Pick & Odds for Thanksgiving Night Football (Nov. 28)

• We’ve made our Memphis vs Tulane prediction for Thanksgiving night football
• The latest AAC odds have the No. 18 Green Wave favored by two touchdowns
• Read below for Memphis vs Tulane prediction, pick and odds on ESPN matchup

The Memphis Tigers (9-2, 5-2 AAC) and the 18th-ranked Tulane Green Wave (9-2, 7-0 AAC) are set to clash in a mouthwatering AAC showdown on Thanksgiving night. This game has all the ingredients of a classic, with Tulane looking to keep its College Football Playoff dreams alive and Memphis aiming to play spoiler.

Yulman Stadium in New Orleans will be rocking when these two high-powered offenses take the field at 7:30 PM ET on ESPN. The stakes couldn’t be higher, with Tulane needing a win to secure home-field advantage for the AAC Championship game against Army.

The books have installed Tulane as 14-point favorites, with the total sitting at 56.5 points. Can the Green Wave keep rolling, or will the Tigers shock the college football world? Let’s break down our Memphis vs Tulane prediction.

Memphis vs Tulane Prediction

Tulane has been flat-out dominant this season, reeling off eight straight wins since those early September losses to Kansas State and Oklahoma. The Green Wave have been absolutely crushing conference opponents, with five AAC victories by 30+ points.

Quarterback Darian Mensah has been the catalyst, completing 65.9% of his passes for 2,197 yards, 18 touchdowns, and just four interceptions. But the real star has been running back Makhi Hughes, who leads the AAC with 1,291 rushing yards and 15 touchdowns.

There goes @HughesMakhi 💨#AmericanWay x @GreenWaveFB pic.twitter.com/BXq7PDl5e8

— The American (@American_Conf) November 16, 2024

On the other side, Memphis has been no slouch. The Tigers boast a 9-2 record and a dynamic offense led by quarterback Seth Henigan (2,990 passing yards, 21 TDs) and running back Mario Anderson Jr. (1,115 rushing yards, 16 TDs).

But here’s the thing: Tulane’s defense has been on another level. The Green Wave have allowed a measly nine points in their last three games combined and rank 12th nationally in scoring defense (17.0 points per game).

Memphis’ defense, while solid, hasn’t been nearly as dominant. The Tigers rank 61st in scoring defense (22.6 points per game) and could struggle to contain Tulane’s multi-dimensional attack.

Recent history also favors the Green Wave, who have won the last two meetings against Memphis, including a 31-21 road victory last season. Tulane is 7-1 ATS in its last eight games, while Memphis is just 1-5 ATS in its last six against Tulane.

When you put it all together, it’s hard to bet against Tulane in this spot. The Green Wave have been the better team all season, and their defense should be the difference-maker against a potent Memphis offense.

• Prediction: Tulane 34, Memphis 24
• Pick: Tulane -14 (-110)

Memphis vs Tulane Odds

Tulane is a heavy 14-point favorite in this matchup, with the over/under set at 56.5 points. The moneyline odds are Tulane -490 and Memphis +365.

According to the implied probability, Tulane has a whopping 83.05% chance of winning the game outright, while Memphis has just a 21.51% chance of pulling off the upset.

It’s not hard to see why the oddsmakers are so high on Tulane. The Green Wave have been dominant in conference play and boast a suffocating defense that ranks among the nation’s best.

The over/under of 56.5 points feels about right given the offensive firepower on both sides. Memphis has seen the over hit in four of its last five games, while Tulane has been more of an under team at home (10 of last 12).

Odds as of Nov. 27, at ESPN Bet. Check out ESPN Bet reviews or browse other top sports betting sites.

Memphis vs Tulane Head to Head

Memphis may lead the all-time series 24-15-1, but Tulane has had the upper hand in recent years. The Green Wave have won the last two meetings, including a 31-21 road victory last season.

In last year’s meeting, Tulane rallied from an 11-point third-quarter deficit to stun Memphis 31-21 at the Liberty Bowl. Makhi Hughes led the way with 130 rushing yards and a touchdown.

The head-to-head trend is clear: Tulane has been the better team in recent years, and the Green Wave have had no trouble winning on the road against Memphis. That bodes well for their chances in this huge Thanksgiving night clash.