Colorado vs Kansas Prediction, Odds & Spread (Saturday, Nov. 23)

• Kansas (4-6) hosts No. 16 Colorado (8-2) in one of the biggest games of the college football weekend Saturday at 3:30 p.m. on FOX.
• The Jayhawks have won four straight against the spread, Colorado eight in a row.
• Check out our primetime preview for Buffs vs Jayhawks, including a look at the best odds, analysis and prediction.

It’ll be the first meeting since 2010 when Kansas (4-6, 4-6 ATS) hosts Colorado (8-2, 8-2 ATS) Saturday afternoon at Memorial Stadium.

The weather forecast in Lawrence calls for a sunny afternoon with temperatures in the upper 50s at kickoff.

Coach Prime and the Buffs have won four in a row and have risen to the top of the Big 12 standings, while Kansas is coming off back-to-back wins over ranked opponents for the first time in school history.

Buffs. Rock Chalk. There’s plenty to get into, and we’ve got everything you need to know before clicking on your favorite sportsbook app.

Colorado vs Kansas odds

Odds as of November 22 at Caesars Sportsbook. Be sure to check out this and our other industry-leading Caesars Sportsbook promos before making a bet on any Week 13 CFB matchup.

Colorado is favored by a field goal or less on the road. Coach Prime’s guys are 2.5-point favorites at BetRivers and FanDuel, and three-point favorites at DraftKings and BetMGM. The line has been steady. It opened at 1.5 at FanDuel, then jumped up a point.

The total is locked in at 59.5 everywhere. The best Colorado moneyline bet is -142 at DraftKings and +125 for Kansas at BetMGM.

There are some obvious trends here, but something has to give. Colorado has covered in their last eight games (no wonder the Colorado alumni love Coach Prime). Four of their last six games have hit the over.

Kansas has been underdogs in their last three games and won all three. They’ve also won four in a row against the number, and five of their last seven games have gone over.

“A unicorn’s just different. It’s hard to do what the unicorn can do”

Calling Travis Hunter ‘different’ doesn’t quite describe the amazing absurdity he accomplishes every weekend

His Heisman campaign manager Shedeur Sanders put it plainly – give 12 his trophy #Denver7 #HE12MAN pic.twitter.com/SeHUD9o0Y8

— Nick Rothschild (@nick_rothschild) November 22, 2024

Buffaloes On The Run? Nah

Colorado continues to defy common football trends. The Buffs rank last (dead last) in rushing yards in college football with 770 this season.

But when you have Shedeur Sanders at QB and Travis Hunter all over the field, you let those guys cook, right? Hunter is a Heisman candidate with 911 receiving yards (14th in nation) and 74 catches (sixth). Sanders has thrown for 27 touchdowns and is a walking highlight.

Kansas has not fared well against the pass on defense. They rank 81st in the country against the pass, but they do have a pair of outstanding cornerbacks in Mello Dotson (five picks) and Cobee Bryant (four). The head-to-head matchup of Bryant vs Hunter is one of the big storylines entering the game.

“I already marked this on my notes,” said Bryant. “I already know this is the game I’ve been wanting all season. Yeah, this going to be the game.”

Devin Neal TD ‼️ KU 17, BYU 13 pic.twitter.com/jx7HSg4yR8

— Kansas Football (@KU_Football) November 17, 2024

Kansas On The Run? Yeah.

The Jayhawks were a pre-season favorite in the Big 12, but lost five in a row after Week 1, but four of those losses were by a touchdown or less. They are now – as the saying goes – playing their best football.

Quarterback Jalon Daniels has been the Jayhawks’ starter off and on for the last five years. He’s a competitor, not the most accurate thrower, but tough, and can run.

Kansas’ offense relies on running back Devin Neal, who has 926 yards and 12 touchdowns. Colorado’s run defense has been an unsung hero for the team this year. They have only allowed 144 yards on the ground in their last two games.

Colorado vs Kansas Prediction

• Colorado -2.5 at FanDuel
• Over 59.5 at FanDuel

Let’s start with the total first. Both of these teams want to get up and down the field. Colorado is the best school in the nation at big plays, but Daniels is good, too for Kansas. This one could be 28-28 at halftime.

Maybe we’re suckers, but we’re buying the Coach Prime stock right now. Colorado can smell the Big 12 championship game and potential spot in the playoff. Big-time players make big-time plays in big-time games. Colorado has a bit more in that department. It’s close, but we like the Buffs to cover.